Dr. Anurag Singh: Urolithin A, Mitophagy, and Mitochondrial Health

Most people think fatigue, muscle loss, and brain fog are just part of aging, but these changes often reflect a deeper issue happening inside your cells. Declining mitochondrial function may be one of the main drivers behind reduced energy, slower recovery, and long-term health decline. In this episode of Extend, I sit down with Dr. Anurag Singh, Chief Medical Officer at Timeline, to unpack the science behind urolithin A and how mitochondrial health impacts muscle, brain, and immune function. We explore how the gut microbiome influences this process, why most people don’t produce enough urolithin A naturally, and what clinical research shows about improving cellular function. We break down how mitophagy works, why mitochondrial quality declines with age, and how this affects strength, endurance, cognition, and immune resilience. We also explore how supplementation, combined with strategies like creatine, magnesium, vitamin D, and NAD precursors, can support long-term performance and recovery. ✅ We also discuss: ➡️ What mitochondria actually do and why they matter. ➡️ Why most people don’t produce urolithin A naturally. ➡️ Mitophagy and cellular cleanup with aging. ➡️ Muscle strength, endurance, and recovery. ➡️ Brain health and cognitive performance. ➡️ Immune function and inflammation. ➡️ Clinical trial results across different populations. ➡️ How to think about dosing and supplementation. ➡️ Synergies with creatine, magnesium, and vitamin D. ➡️ NAD, NR, and NMN for mitochondrial support. Subscribe for science driven conversations on longevity, performance, and the strategies that help you optimize your healthspan. Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram:   / darshanshahmd   Learn more about Dr. Anurag Singh: Website: https://www.timeline.com/ Thank You to Our Sponsors: Timeline: Timeline powered by Mitopure just dropped the price. Check it out at http://timeline.com/drshah and get an additional 20% off your first month with code DRSHAH. Momentus: Head to livemomentous.com/fiber and use code DRSHAH for up to 35% off your first order. Hashtags: #MitochondrialHealth #UrolithinA #Mitophagy #CellularHealth #LongevityHealth #GutMicrobiome #MuscleHealth #BrainHealth #ImmuneHealth #MetabolicHealth #RecoveryPerformance #BiohackingHealth #HealthyAging #DrDarshanShah #ExtendPodcast